A Duramax with no load on it, seldom runs much hotter than 180.
And a thermostat does not increase engine cooling. If your engine runs under load at 210, the thermostats ain't going to change that much. In any case, it's oil temp that is the danger, and it runs hotter than the water, even though it has a water/oil heat exchanger.
The trick behind these thermostats is they open much, much faster than the stock ones do. We needed them for Bonneville, so we tested a whole bunch of different ones until we found the ones that open the fastest.