Pretty sure mine is broken at the #2 since it still ran and I can move the balancer. Crank was out of a bone stock Kodiak, was magged, balanced, ATI balancer, 15.5:1 compression, electric fans, single CP3, electric water pump, motor was only in for less than a year and only had about 5,000 miles on it. Had 3.42 gears and 5 speed that put me in the sweet spot Mark is talking about, was cruising for about an hour, came to a red light, when I started to pull away it started knocking.
With no water pump, no fan, and only a single CP3 I don't think it had to do with load on the snout; previous build had dual fuelers, and a mechanical water pump (or 14 before going electric), was pushed harder and abused more, and didn't hurt the crank.
With aftermarket cranks, internal balance, ATI or Fluid Dampers, billet mains and girdles, and lower compression all not preventing crank failures I personally think that our stock firing order creates a frequency at a certain RPM range. The alternate firing order will change that frequency. Internal balancing certainly won't hurt, and personally I'll be using a new crank in my next build. They are like $950, so they are cheaper than the alt firing cam. I figure that way I know that the crank hasn't already been fatigued.