I've probably had more sets of compound turbos than just about anyone. From mild to extremely wild. As was said by Pat, you have to decide what kind of performance you want from your truck, what you will be using it for, and how much $$ your are willing to spend to get there. The only single turboed truck that I ever had other than a stock one was I put an A2000 as my first turbo change on my 02 CC/DB GMC. Didn't really see any difference in it from stock.
I Had the second set of twins ever put on a LB7 and those would push about 42 psi, and that truck ran 12.0. I currently have a nice set for sale that uses a GT4202 as the big charger. It's considered the small set for a LBZ. I had the same set up on my 07 CC that I sold and I've never had a more fun street truck. Never changed the tune, ran the samething track or tow. Ran 12.6 @107, got 21+mph on the highway, 17 around town, and 13+ towing my travel trailer. Never got hot and as smooth as silk with almost no lag. Makes about 50lbs of boost. I had my gated and tuned to run about 43lbs.
Most guys who have never had twins try and stomp on them to go. You get better and quicker results if you ease into the throttle.:thumb: Turbo whistle is also very nice if you are into that.
Again all depends on what you want from your truck. I'm obviously very biased. FWIW, the quickest dmax in the country, (Buck Spruill) is going to twins, or at least that was my last information. Buck or Jess if that is incorrect let me know.