It's not so much the fender as it is the driver's side firewall. The 2468 head is further back, and the brakes and steering make it clumsy to boot.
A single "stock disp" CP3 is not normally going to generate enough torque to bend rods.
Dual CP3's or a big CP3 with a big charger usually will.
Check prices with SoCal Diesel for head gaskets and other components as well, you might save money over what GM charges.
Here's the problem you are going to run into, I'll use myself as an example, but I'm not unique:
I wanted my Duramax to tow a bit better, so I put on an exhaust and 50HP tune.
I liked it! If I would have stopped there, my kids would be going to Harvard instead of community college.
But I didn't. I ran a 100HP tune, and liked it better.
Now I needed a built trans.
Then I started stacking and tried a "small" shot of nitrous.
Then when Kat sold her minivan, we bought a second Dmax. This one we were going to use for the business and my daily driver. But I wanted it to run 12.99 on fuel, and 11.99 on the bottle.
If I would have stopped there, the kids would be going to UCI.
Then I put on a BD charger, not enough.
Then I put on a HTT charger, not enough.
Now I added dual fuelers, 11.77 on fuel.
Now a GT4088, not enough.
Now a GT4202R, and bent the rods at 754HP.
Now a built engine, and 10.83 on fuel, 10.59 with a small shot.
If I stopped at this stage, they could go to Cal State Fullerton.
Now twins, 916rwhp, 197mph, etc.
Cliff notes: stock rods are usually fine if you have good sense to stop at 650HP. If you have the Speed Disease, you should REALLY put in good rods, key the cam, key the crank, headstuds, high speed springs, cut the pistons, etc.