Not to add fuel to the fire, but a big single can do it all as well. For one it is ALOT cheaper and easier to setup a big single compared to compounds. Next I tow with my S475 and don't have any problems with EGTs, granted the east coast is pretty flat and another DMax is typically my heaviest load - but this guy lives on the east coast and tows a 5K boat. Also you can get as much power out of a 3.0 single as you can a 2.6/3.2 compound setup. An S480 as a single would put you around 1,000hp, while as the big turbo in a compount setup 800-900 is the max before EGTs get out of hand. On top of all that many sled pulling organizations put twins in the unlimited category, meaning you are pulling against guys with open drivelines, drop boxes, and tube chassis.
Now all that being said, I would recommend 4.56 gears with the 37s. That will get you back to the correct RPM range, which will help with any turbo setup. If you don't plan to all out race the truck or sled pull, and have the extra money I would recommend a compound setup - for this application. With the right tuning 60% over injectors won't be an issue and if you can afford it SoCal Diesel is the place to send them. For the trans I would recommend a Stage IV build by a reputable shop, and I prefer the Precision Industries converters. For that setup I would charge $4200 all inclusive, out the door - I'm sure SunCoast would be alot more, but I am more of a drive. I could work out a package deal for the lift, tires, rims, gears, twins, trans, EGR delete, injectors, tuning, and all installed too.