IMO a D60 with big shafts can last in most 3.0 trucks. The R&P might start being a problem for the baddest 3.0 trucks though. And yes, even an IFS can work in big power situations with some fancy goodies. It'd be interesting to see how an ifs would last in a top-performing 3.0 truck.
If going mod class (where the sigma pumps & triple chargers & billet heads/blocks are) you're gonna need more beef out front, period. Enter, big GM military steer axle or F106 with big shafts, spindles & locker/spool.
Most say the F106 rear can be built stout enough to last in most 3.0 trucks except maybe the baddest ones in the country. I believe the SQHD is one of the stoutest one used except built sheet metal rear ends. And even then, they use the diff from an SQHD and the sheet metal just allows it to be lighter weight than the original SQHD housing/center & humongous axle tubes.
So what are you building? Tube chassis mod/open truck or A 3.0 ODL truck?
I hate to do it but there's some really good discussions on this topic over on CompD too.