I think its just a very weak design. If you look at the crank and the overlap from the rod journal to the main journal there just isn't enough metal there. Banks I think made a new crank with a bigger rod journal to help with that. Harmonics plays a rule and I think a hard shift or harsh lockup also plays a rule. I really don't think the AF cams do a lot but if your buying a cam it can't hurt.
I wouldn't say its a weak design when kept within the designers original max power output... The problem is that many of todays diesel engines are easy to turn up, far exceeding the original design limits. I'm sure if Isuzu was told the crank needs to withstand 2000hp and 3000tq they would have built it slightly beefier:rofl: