If you search the site, you will find lots of members use water to air intercoolers, primarily for sled pulling, but sometimes drag racing.
You absolutely can run a water to air intercooler, but it normally isn't done for street use, except when you can't fit an air to air, because it costs more.
For competition, usually all you need is a water to air, a pump, and a tank/ice box. But for street use, you also need another water to air to get the heat back out, or you'll be stopping every 15 minutes to add more ice. When you price TWO water to air units of sufficient size, and the pumps, etc., it doesn't make sense if you can fit a air to air.
In your case, it might be the right answer. If you search around on the site, you can find lots of info on what sizes you need, etc. I've never run one, so I can't say much more specifically. Just search, read, and learn!
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