When my trans was stock, I would slap it in R all the time at 70 MPH to dick with tailgaters (backup lights come on). Never hurt anything. I would let it go into neutral as well, and never had any noises or issues.
My first built trans tied up in neutral at 35 MPH, locked up the rear tires. It was fine for a second, then the C5 must have come on before whatever clutch let off, because BANG! and the rear tires stopped dead... Current built trans handles it better, just a thunk but no jolt the one time I hit neutral by mistake. So don't go to neutral on a built trans, they don't handle it well.
If you are stock, do what you want, GM will fix it :spit:. I've never personally seen a stock trans have a problem going to neutral while moving, but your mileage may vary.