You want to size it based on the optimization of where the kit will spend the most of it's time. A race kit will not have the same setup as a DD kit. I would talk to one of the well known kit makers about what your goals are.
The high pressure turbo does 2 things.
1. being smaller it spool much better, giving it more DD ability. Most of the time you are driving 95% on just the high pressure turbo.
2. It compresses the air in addition to what the primary or atmo/ low pressure turbo(s) are. A single stage of compressor can only do so much "work" mass flow with compression. The secondary (HP) turbo does additional work to that air to further compress it (obviously not with more mass flow that is set from the primaries). You do not want to do any extra work to the air, you only compress it enough to overcome the restriction (ie the intake).
You don't want to do more work than necessary to the air since it only adds heat (the air can be over 500*F coming out of the high pressure turbo) and doing extra work only creates more backpressure and temps on the turbine side of things.
So that is why I like the idea of a tight, small turbine on the HP turbo with a big waste gate, quick spool then run it at a lower CR than if it was single, and look at the rest of the engine to keep the mass flow going without the higher CR. Heat is not what you want on the intake side, heated air takes up more area per mass.
The high pressure turbo does 2 things.
1. being smaller it spool much better, giving it more DD ability. Most of the time you are driving 95% on just the high pressure turbo.
2. It compresses the air in addition to what the primary or atmo/ low pressure turbo(s) are. A single stage of compressor can only do so much "work" mass flow with compression. The secondary (HP) turbo does additional work to that air to further compress it (obviously not with more mass flow that is set from the primaries). You do not want to do any extra work to the air, you only compress it enough to overcome the restriction (ie the intake).
You don't want to do more work than necessary to the air since it only adds heat (the air can be over 500*F coming out of the high pressure turbo) and doing extra work only creates more backpressure and temps on the turbine side of things.
So that is why I like the idea of a tight, small turbine on the HP turbo with a big waste gate, quick spool then run it at a lower CR than if it was single, and look at the rest of the engine to keep the mass flow going without the higher CR. Heat is not what you want on the intake side, heated air takes up more area per mass.