Well, I can't speak for other tuning, but PPE's defuel is HORRIBLE with the bigger tunes (at least on my truck). After Mike's warning about tie-ups with big tunes and no defuel, I only ran w/o it on 90 and lower. My main concern is/was tie ups and MAJOR catastrophic damage. If/when Mike figures out how to prevent tie-ups altogether, I'd be very interested. I can handle replacing clutchpacks every year or two due to accellerated wear from non-defueled shifts. IMO, once the TCM learns, non-defueled shifts feel TONS better. I just want to avoid KA-BOOM! Anyway, I'm going to probably try to get the truck on a lift somewhere soon, get the trans out and get an autopsy done, then go from there. I probably won't run anything big once it's fixed until I get my engine work done (HOPEFULLY this summer, if this doesn't cost a fortune).