Umm Yes yes yes and yes. Ive done it to a 72 blazer. The abs and stuff you don't want you just cut it out abs and airbag lights will be on but those can be removed from the cluster. I however used 90% of the dmax harness and I added power locks and windows of my ow custom fab using 73 and up regulators modded by me
It basically boils down to your skill level. My truck runs the Lb7 Twin turbo'd Suncoast Allison w 6 speed conversion, Dana 60 driver side drop front axle w big brakes and abs, 205 Driver side drop tcase, AMM rear axle w disks, I did NOT use the factory column Nor ignition switch its all hooked up to my factory ign switch w use of some diodes and thought.
Putting the 205 onto the Allison and making it electronic speedo was fun. mating the factory fuel pickup, cup and sender unit to the factory tank was fun too.
But it all depends on you really