Be careful driving in 5th gear with it for a little while. Let the transmission learn the new values, or it will bug out and limp. As far as 1-2-3-4 it will be fine if your trans doesn't have any current issues. Now, I'm not saying it's trans safe... I don't recommend over 100. But yes i do run a 200tune.
Yeah my trans is in perfect running condition as of right now at almost 250k miles. I already let off of the shifting with my 5th tune which i think is an 100 tune, still havent limped my trans once since owning the truck