Track prep, how they handle the waterbox, and how stiff your rear is (don't say it!
) are more important with our heavy trucks than tire selection is. I've went 1.7x on the factory tires, and 2.0x on 12" wide drag tires. Nothing makes BVD stains darker than struggling to get traction in a 3-ton kinetic energy weapon.
For safety, it is better to run race tires if you are above 650HP, since you don't get to chose the track conditions. While drag racing our trucks has an excellent safety record, most the crashes were due to insufficient traction between the 330' line and 1/8th mile.
Unlike most cars, our trucks can build a lot more power at 330' than off the line, and due to the expense of VHT, they often don't spray it past the 330', nor is there as much rubber laid down at many tracks.
The biggest danger comes with using DOT race tires on the street. They suck hard in the rain, handle like a boat, pickup nails like a magnet, and don't like sustained heavy loads. If you must run DOT race tires on the street, keep speeds down and pressure up. Both help reduce the heat, which is what causes sudden blowout disease.
I drove 20 miles back to the hotel from the Bandimere event in POURING rain on M&H DOT drag radials. I made it OK, but ... not bright. On the way home, Big Blue (our tow vehicle) lost a tire, and I put one of the M&H's on and it didn't make it 10 miles before it exploded. Something to think about.