On the MIKELB7 charts, the scary one is the WOT balance rate. 14% difference between cylinders????
To put that in perspective, you would being tuning the average of the cyls. Some cyls would be down 7%, others would over by 7%. Or with a 500 horse engine, 535hp fuel in some, and 465hp in others. The failure limit is the high cyl, so let's say you hurt the rods or pistons at 700hp in a balanced engine. You'd hit the failure point when you tuned it to 651hp.
Injector balance is perhaps the #1 concern when pushing against the limit.
thats a little scarey