You will tax the cooling system quickly and 4th gear will be an issue if you try to use any of that power while towing. Trans will need a good build unless you keep it in 3rd under power pulling hills. We ran a whipple supercharger on my moms 98 cc/lb 454 GMC. Truck was lifted on 35s and towed a 35ft Alfa toy hauler and a 40ft weekend worrier. Had 75k on it when we sold it and a stock 4l80 but my dad never overly abused the truck when towing. Would always kick it to 3rd on hills and was always worried about breaking something so never really wooded it. Only time I remember was in pismo beach when we had to make a loop up into the soft sand. 30psi in the back tires, 25 in front and trailer down to 20 on all 6. 4 low 3rd gear, that motor and super charger sung a beautiful tune. We were the only truck of the camp to make the turn without getting stuck lol. Truck made somewhere in the 400-450 range on a cool day.
If you are smart with it, I see no reason it will tow just fine. Just still won't be like a dmax and an Allison. That said, you know I'd build it and try to make it work