I'll explain my experience with the different models and rail pressure vs HP. on a stock CP3 average fuel system in decent shape.
I like to think of a teter-toter. Pulse width on one side and pressure on the other side. You have to find the balance for most available HP.
As was posted earlier; the LB7/LLY trucks will be happy making 19k rail pressure on a big fueling tune. Would it make more HP with more pressure? heck yeah. The LBZ/LMM trucks that low limit of balance is 23,500-24,000. Anything below that and you will start dropping HP fast.
My big tunes 3100-3200us on stock injector/stock cp3 trucks have that as the max and when rail pressure drops, so does the pulse. This way the ecm should fine the balance of pulse to pressure. If the system can't keep up at 3100us than as the pressure drops, the pulse will be pulled back.
I have tested this over many years and many trucks on the dyno and the track. If the truck can't keep this balance of pressure to pulse, then the fuel system most likely needs some attention. Here is a write I did that may help.
http://atptrucks.com/blog/fuel-rail-pressure-is-low-now-what
I don't recommend adding a second CP3 without tuning adjustment on a stock engine. This will now make a 3200us tune to run at 26k psi. Big HP, enough to kill a stock block. I will adjust the tuning as per a customers request for HP after explaining the possible failures. Most choose to lower pulse to a more sane level and have the 26k psi.
Hopefully this helps a bit explain how I think of things. Basically I build tuning from many years of experience on what the average truck (and customer) can handle. Fine tuning can be done to optimize each set-up and needs.