EFILive is a tool. It allows you to change engine and transmission tables individually and will record engine operation data. EFILive is used in conjunction with an IBM PC.
PPE Hot +2 is a handheld tuner that can also display engine operation data. It does not require a computer to use, or any tuning knowledge.
Which one is right for you depends on your goals for your truck. The PPE is the most intense of the handhelds, there is nothing more powerful out there. It is very simple to use, and has 10 power levels built in.
EFILive give you more flexibility and features than any handheld, and you can fine tune your engine combo for the absolute max performance, but at the expense of complexity. If you are not comfortable around a computer, or you want the simplest route, it is not for you. It's not incredibly difficult to use, but is a lot more difficult than a PPE.